I received my PhD in Computer Science from Duke University in 1997. In August 2014, following a faculty appointment at Montana State University Department of Computer Science, and nearly 15 years as CEO of a bioinformatics software company, Golden Helix, I became a faculty member in the University of New Mexico Center for Global Health, Division of Translational Informatics, and Department of Internal Medicine.

My research areas include clinical research informatics, bioinformatics, and systems thinking. I develop and apply methods for the analysis of longitudinal healthcare data for predictive and preventative medicine. Since its inception, I have collaborated with other members of the Observational Health Data Sciences and Informatics collaborative. The OHDSI/OMOP common data model has been adopted to represent over 500M patients' electronic health and/or administrative claims records worldwide, enabling the development of a broad set of tools for the analysis of human health on these massive datasets. I am currently developing statistical and computational tools to compare treatment options and obtain better estimates of expected health outcomes despite large biases and confounding in the data, with a focus on mental illness (bipolar disorder, major depression, PTSD, suicidality), with pilot projects in human aging.

In July 2016 I received an NIH NLM R21 award to research methods for observational comparative effectiveness research, and a  PCORI award to compare bipolar disorder treatments and outcomes in large-scale administrative claims data.In 2020, I received an R56 award from the NIH NIMH to investigate undiagnosed and/or unrecorded PTSD, TBI, and self-harm through machine learning to determine the degree to which this phenomenon exists, and to examine disparities in diagnosis/recording/outcomes by patient sociodemographic factors. Recent results of this work were presented at the 2021 OHDSI Global Symposium. 

In addition, I perform bioinformatics analyses of genomics datasets with current projects in pediatric Malaria and COVID-19 in collaboration with Dr. DJ Perkins in the Center for Global Health. I serve as the UNM Clinical and Translational Sciences Center (CTSC) Informatics Core Lead. I hold secondary appointments in the UNM Department of Psychiatry and Behavioral Sciences and the UNM Department of Computer Science.

I inform all of my efforts through a palette of multiple systems disciplines including Theory of Constraints, System Dynamics, Requisite Organization, TRIZ, Cybernetics, and the Scientific Method.